Thermal Analysis and Rheometer Systems – TA Instruments

<body> <h1><span lang="en-us">Welcome to Thermometric</span></h1> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> Thermometric focuses on thermal measuring techniques, with emphasis on isothermal microcalorimeters. The company is located in the Stockholm area in Sweden.</span></p> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> The calorimeter systems from Thermometric are modular, hierarchically structured ranges of products that can be assembled in a variety of configurations to meet the needs of the user. </span></p> <h2><span lang="EN-US">Products</span></h2> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> Our four main systems are TAM III, 2277 TAM, TAM Air and SolCal. </span></p> <h3><span lang="EN-US">TAM III</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> TAM III is the new generation multichannel microcalorimetric system from Thermometric. Up to four independent calorimeter units can be used simultaneously. A unit can be a 4 ml nanocalorimeter for measurements, which require very high sensitivity, a 20 ml standard microcalorimeter, a multicalorimeter consisting of 6 minicalorimeters or the semi-adiabatic solution calorimeter. The multicalorimeter increases sample throughput considerably for applications where microwatt rather than nanowatt sensitivity is sufficient. TAM III also exists in a 48 Channel version for screening applications, or in general, when high sample throughput is required. </span> </p> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> TAM III can be operated in isothermal, step-isothermal or slow temperature scanning mode. The isothermal mode is the classical mode for microcalorimetric experiments. Another new feature is feed back titration calorimetry for fast and sensitive and titrations (ITC).</span></p> <h3><span lang="EN-US">2277 TAM</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> Our classical 2277 TAM microcalorimeter system can be equipped with four calorimeters such as ampoule calorimeters, flow calorimeters, flow-mix calorimeters and solution calorimeters. A wide range of ampoules is available: closed system ampoules in glass and stainless steel, open ampoules such as titration ampoules, RH-perfusion ampoules and gas or liquid perfusion ampoule. For our 20 ml ampoule calorimeter there is a microsolution ampoule available.</span></p> <h3><span lang="EN-US">SolCal</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> The Precision Solution Calorimeter is a semi-adiabatic (isoperibolic) calorimeter used for quantification of the heat released or absorbed as a sample is dissolved in a liquid solvent. The calorimeter exists in two different versions. One is for experiments involving an ampoule break reaction, the other for both ampoule breaks and titrations. </span></p> <h3><span lang="EN-US">TAM Air</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> TAM Air is an 8-channel heat conduction calorimeter for heat flow measurements in the milliwatt range under isothermal conditions. The calorimeter is recommended for applications not requiring the highest sensitivity offered by 2277 TAM and TAM III. TAM Air is a versatile instrument which supports a wide range of applications. A few examples include cement hydration, metabolism of micro-organisms and small animals, fermentation processes, microbial degradation of food stuffs and assessment of efficiency and life expectancy of batteries. TAM Air is also excellent for educational purposes, because of the robust design and ease of use.<br> </span> <span class="CharChar"><span lang="EN-US" style="font-size:13.0pt">Accessories</span></span></p> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> Different auxiliary equipment can be connected to TAM – thermal activity monitor - systems. These accessories include peristaltic pumps for perfusion of liquids, syringe pumps for titration calorimetry and a gas flow control kit. </span> </p> <h3><span lang="EN-US">Courses</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> Thermometric AB also offers basic hands-on courses in calorimetry, solution calorimetry, titration calorimetry and RH-perfusion calorimetry.</span></p> <h2><span lang="EN-US">Applications</span></h2> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> Due to the fact that heat is associated with virtually all processes in nature calorimetry has found applications in a wide range of disciplines within academic science and industry. Examples include material sciences, pharmaceuticals, life sciences and general chemistry.</span></p> <h3><span lang="EN-US">Pharmaceuticals</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> In the pharmaceutical science our microcalorimeters are used to investigate chemical decomposition, drug excipient compatibility, amorphicity, analysis of disorder in highly crystalline materials, polymorphism, hydrates and solvates, ligand binding and many other characteristics of compounds that are important in pharmaceutical research and development. Stability data can be obtained within hours in contrast to many other techniques, which requires accelerated conditions to obtain data within a comparable time frame. TAM III is an ideal tool for compatibility screening at ambient temperatures and humidities without the need to dissolve or in other ways alter the sample prior to analysis. Quantitative and qualitative investigations of amorphicity and crystallinity are of particular interest, much due to the high sensitivity of TAM. TAM III can detect amorphous amounts of less than 1%. TAM III can be used in slow scanning mode (e.g. 2 K h</span><sup><span lang="EN-US" style="font-size:10.0pt;font-family:Arial;color:black">-1</span></sup><span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black">) with a temperature resolution that widely exceeds that of conventional DSC. This is of particular interest for studies of glass transitions of amorphous samples as well as phase transitions of polymorphs and hydrates</span></p> <h3><span lang="EN-US">Life Science</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> In life sciences TAM has proven to be very useful for the study of metabolic activities of living organisms such as bacteria, yeast, mammalian cells and tissues, seeds and small plants. Further, isothermal titration microcalorimetry is an established tool for investigations of interactions between molecules of biological relevance (e.g. proteins, DNA, lipids, drugs) and enzyme kinetics. Isothermal microcalorimetry has proven to be very useful for the study of metabolic activities of living systems and in measurements of cellular and biomolecular interactions. The technique has the advantage of being general, non-destructive and very sensitive, thus enabling metabolic activities to be monitored in real-time under realistic biological conditions. Examples include effect of drugs on cancer cells, microbial growth, compatibility assessments of mammalian cells with various materials, enzyme kinetics and interaction between membrane bound protein and drug molecules. </span></p> <h3><span lang="EN-US">Material Sciences</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> In the material sciences field TAM III can be used for stability assessments on polymers and other materials, explosives, propellants and other energetic materials under a range of different environmental conditions. Conditions that can be changed include temperature, humidity and the composition of the surrounding gas phase. Other applications include compatibility screening, materials testing, such as film permeability, as well as investigations of various physical phenomena, such as glass transitions. The slow scanning function of TAM III allows various kinds of phase transitions to be monitored with considerably higher temperature resolution than what is possible with conventional DSC. This enables measurements of close consecutive events to be performed with a very high temperature resolution.</span></p> <h3><span lang="EN-US">Chemistry</span></h3> <p class="MsoNormal"> <span lang="EN-US" style="font-size: 10.0pt; font-family: Arial; color: black"> There are a wide range of applications within general chemistry including stability or compatibility, molecular interactions in solution, kinetics in the liquid or solid state and general thermodynamic investigations of liquid solutions and solid materials. An example of stability applications include the assessment of safety criteria associated with the handling and storage of unstable substances such as percarbonates, peroxides, and propellants. Molecular interactions are preferably studied by isothermal titration calorimetry (ITC). Kinetic analysis has been performed on different kinds of liquids such as the oxidation and subsequent hydrolysis of ascorbic acid and hydrolysis of acetylsalicylic acid.</span></p> </body>